Life's essential 8 and risk of subclinical atherosclerosis pro- gression: a prospective cohort study

Zhou, Shi-Yu1,2; Liu, Fang-Chao1,2; Chen, Shu-Feng1,2; Li, Jian-Xin1,2; Cao, Jie1,2; Huang, Ke-Yong1,2; Tang, Zheng-Hao1,2; Liang, Feng-Chao3; Hu, Dong-Sheng4,5; Zhao, Lian-Cheng1,2; Li, Ying1,2; Huang, Jian-Feng1,2; Lu, Xiang-Feng1,2; Lu, Bin6; Gu, Dong-Feng1,2,3

2024

10.26599/1671-5411.2024.07.005

JOURNAL OF GERIATRIC CARDIOLOGY   影响因子和分区

1671-5411

BACKGROUND Previous studies have demonstrated the benefits of ideal cardiovascular health (CVH) in reducing cardiovascular risk. However, its role in subclinical atherosclerosis (SA) progression remains unclear. We aim to examine the association of CVH, estimated by the American Heart Association's new Life's Essential 8 (LE8), with the progression of SA. METHODS This prospective cohort study was conducted among 972 asymptomatic Chinese participants and followed up for 5.7 years. The LE8 score (range, 0-100) consisted of blood pressure, lipids, glucose, body mass index, smoking status, diet health, physical activity and sleep health was evaluated in 1998 and 2008-2009. Progression of SA was determined by carotid plaque and coronary artery calcification (CAC) in 2008-2009 and 2013-2014. Log-binomial regression model was used to estimate the association of LE8 score with SA progression. RESULTS Each 10 points increment in LE8 score was associated with 15.2% % (RR: 0.848, 95% % CI: 0.797-0.902), 17.7% % (RR: 0.823, 95% % CI: 0.766-0.884) and 12.0% % (RR: 0.880, 95% % CI: 0.845-0.916) lower risks of carotid plaque, CAC and overall SA progression, respectively. Compared with participants with non-ideal CVH at both visits, the participants with ideal CVH at both visits had 39.1% % (RR: 0.609, 95% % CI: 0.494-0.752), 41.0% % (RR: 0.590, 95% % CI: 0.456-0.764) and 29.7% % (RR: 0.703, 95% % CI: 0.598-0.825) lower risks of carotid plaque, CAC and overall SA progression, respectively. CONCLUSIONS Higher LE8 scores were associated with lower risks of SA progression. Besides, long-term maintenance of optimal CVH was more beneficial to prevent SA progression.

SCI

英语

通讯

Chinese Academy of Medical Sciences (CAMS) Innovation Fund for Medical Sciences["2021-I2M-1-010","2019-I2M-2-003","2017-I2M-1-004"] ; National Natural Science Foundation of China["82030102","12126602","82330106","82322059","91857118"] ; National High Level Hos-pital Clinical Research Funding["2022-GSP-GG-1","2022-GSP-GG-2"] ; National Key Research and Development Program of China[2021YFC2500500]

Cardiovascular System & Cardiology ; Geriatrics & Gerontology

Cardiac & Cardiovascular Systems ; Geriatrics & Gerontology

WOS:001312964300007

TSINGHUA UNIV PRESS

Web of Science

1.Chinese Acad Med Sci & Peking Union Med Coll, Fuwai Hosp, Natl Ctr Cardiovasc Dis, Dept Epidemiol, Beijing, Peoples R China
2.Chinese Acad Med Sci & Peking Union Med Coll, Key Lab Cardiovasc Epidemiol, Beijing, Peoples R China
3.Southern Univ Sci & Technol, Sch Publ Hlth & Emergency Management, Sch Med, Shenzhen, Peoples R China
4.Zhengzhou Univ, Sch Publ Hlth, Dept Epidemiol & Hlth Stat, Zhengzhou, Peoples R China
5.Shenzhen Univ, Hlth Sci Ctr, Sch Publ Hlth, Dept Biostat & Epidemiol, Shenzhen, Peoples R China
6.Chinese Acad Med Sci & Peking Union Med Coll, Fuwai Hosp, Natl Ctr Cardiovasc Dis, Dept Radiol, Beijing, Peoples R China

Zhou, Shi-Yu,Liu, Fang-Chao,Chen, Shu-Feng,et al. Life's essential 8 and risk of subclinical atherosclerosis pro- gression: a prospective cohort study[J]. JOURNAL OF GERIATRIC CARDIOLOGY,2024,21(7).

Zhou, Shi-Yu.,Liu, Fang-Chao.,Chen, Shu-Feng.,Li, Jian-Xin.,Cao, Jie.,...&Gu, Dong-Feng.(2024).Life's essential 8 and risk of subclinical atherosclerosis pro- gression: a prospective cohort study.JOURNAL OF GERIATRIC CARDIOLOGY,21(7).

Zhou, Shi-Yu,et al."Life's essential 8 and risk of subclinical atherosclerosis pro- gression: a prospective cohort study".JOURNAL OF GERIATRIC CARDIOLOGY 21.7(2024).