Unveiling the promise: Exosomes as game-changers in anti-infective therapy

Chavda, Vivek P.1; Luo, Guanghong2; Bezbaruah, Rajashri3; Kalita, Tutumoni4; Sarma, Anupam4; Deka, Gitima5; Duo, Yanhong6; Das, Bhrigu Kumar4; Shah, Yesha7; Postwala, Humzah7

2024-03-01

10.1002/EXP.20230139

EXPLORATION   影响因子和分区

2766-8509

2766-2098

Extracellular vesicles (EVs)-based intercellular communication (through exosomes, microvesicles, and apoptotic bodies) is conserved across all kingdoms of life. In recent years, exosomes have gained much attention for targeted pharmaceutical administration due to their unique features, nanoscale size, and capacity to significantly contribute to cellular communication. As drug delivery vehicles, exosomes have several advantages over alternative nanoparticulate drug delivery technologies. Akey advantage lies in their comparable makeup to the body's cells, which makes them non-immunogenic. However, exosomes vesicles face several challenges, including a lack of an effective and standard production technique, decreased drug loading capacity, limited characterization techniques, and underdeveloped isolation and purification procedures. Exosomes are well known for their long-term safety and natural ability to transport intercellular nucleic acids and medicinal compounds across the blood-brain-barrier (BBB). Therefore, in addition to revealing new insights into exosomes' distinctiveness, the growing availability of new analytical tools may drive the development of next-generation synthetic systems. Herein, light is shed on exosomes as drug delivery vehicles in anti-infective therapy by reviewing the literature on primary articles published between 2002 and 2023. Additionally, the benefits and limitations of employing exosomes as vehicles for therapeutic drug delivery are also discussed.

antibacterial anti-infective antiviral exosomes extracellular vesicles micro vesicles nano carrier viral infection

ESCI

英语

其他

Science & Technology - Other Topics ; Materials Science

Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Multidisciplinary Sciences

WOS:001314148100001

WILEY

Web of Science

1.LM Coll Pharm, Dept Pharmaceut & Pharmaceut Technol, Ahmadabad 380009, Gujarat, India
2.Southern Univ Sci & Technol, Affiliated Hosp 1, Jinan Univ,Dept Radiat Oncol, Clin Med Coll 2,Shenzhen Peoples Hosp, Shenzhen, Guangdong, Peoples R China
3.Dibrugarh Univ, Fac Sci & Engn, Dept Pharmaceut Sci, Dibrugarh, Assam, India
4.Girijananda Chowdhury Univ, Sch Pharmaceut Sci, Gauhati, Assam, India
5.Yeungnam Univ, Coll Pharm, Gyeonsan, South Korea
6.Harvard Univ, Wyss Inst Biol Inspired Engn, Boston, MA 02138 USA
7.LM Coll Pharm, PharmD Sect, Ahmadabad, Gujarat, India

Chavda, Vivek P.,Luo, Guanghong,Bezbaruah, Rajashri,et al. Unveiling the promise: Exosomes as game-changers in anti-infective therapy[J]. EXPLORATION,2024.

Chavda, Vivek P..,Luo, Guanghong.,Bezbaruah, Rajashri.,Kalita, Tutumoni.,Sarma, Anupam.,...&Postwala, Humzah.(2024).Unveiling the promise: Exosomes as game-changers in anti-infective therapy.EXPLORATION.

Chavda, Vivek P.,et al."Unveiling the promise: Exosomes as game-changers in anti-infective therapy".EXPLORATION (2024).