Electroactive differential growth and delayed instability in accelerated healing tissues

Wang, Yafei1,2; Li, Zhanfeng3; Chen, Xingmei1; Tan, Yun1; Wang, Fucheng1; Du, Yangkun4; Zhang, Yunce7; Su, Yipin5,6; Xu, Fan2; Wang, Changguo8; Chen, Weiqiu5,7; Liu, Ji1

2024-12-01

10.1016/j.jmps.2024.105867

JOURNAL OF THE MECHANICS AND PHYSICS OF SOLIDS   影响因子和分区

0022-5096

1873-4782

Guided by experiments contrasting electrically accelerated recovery with natural healing, this study formulates a model to investigate the importance of electroactive differential growth and morphological changes in tissue repair. It underscores the clinical potential of leveraging electroactive differential growth for improved healing outcomes. The study reveals that voltage stimulation significantly enhances the healing and growth of biological tissues, accelerating the regeneration process across various growth modalities and steering towards isotropic growth conditions that do not favor any specific growth pathways. Enhancing the electroelastic coupling parameters improves the efficacy of bioelectric devices, initiating contraction and fortification of biological tissues in alignment with the electric field. This process facilitates swift cell migration and proliferation, as well as oriented growth of tissue. In instances of strain stiffening at elevated strains, the extreme critical growth ratio aligns with the predictions of neo-Hookean models. Conversely, for tissues experiencing strain stiffening under moderate to very low strain conditions, the strain stiffening effect substantially delays the onset of electroelastic growth instability, ultimately producing a smooth, hyperelastic surface devoid of any unstable morphologies. Our investigation, grounded in nonlinear electroelastic field and perturbation theories, explores how electric fields influence differential growth and instability in biological tissues. We examine the interactions among dimensionless voltage, internal pressure, electroelastic coupling, radius ratio, and strain stiffening, revealing their effects on promoting growth and delaying instability. This framework offers insights into the mechanisms behind electroactive growth and its instabilities, contributing valuable knowledge to the tissue healing.

Tissue healing Differential growth Delayed instability Strain stiffening Electroelasticity Electrical stimulation

SCI

英语

第一 ; 通讯

National Natural Science Foundation of China["12425204","12202105","12122204","12372096","12172102","52403160","52373139"] ; Basic Research Program of Shenzhen[20231116101626002] ; Scientific Research Platforms and Projects - Guangdong Provincial Education Office[2022ZDZX3019] ; Shanghai Pilot Program for Basic Research at Fudan University[21TQ1400100-21TQ010] ; Shanghai Shuguang Program[21SG05] ; Guangdong Basic and Applied Basic Research Foundation[2023A1515110532] ; European Union[101105740]

Materials Science ; Mechanics ; Physics

Materials Science, Multidisciplinary ; Mechanics ; Physics, Condensed Matter

WOS:001320667800001

PERGAMON-ELSEVIER SCIENCE LTD

Web of Science

1.Southern Univ Sci & Technol, Dept Mech & Energy Engn, Shenzhen 518055, Peoples R China
2.Fudan Univ, Inst Mech & Computat Engn, Dept Aeronaut & Astronaut, Shanghai 200433, Peoples R China
3.South China Univ Technol, Sch Civil Engn & Transportat, Guangzhou 510640, Peoples R China
4.Univ Trento, Dept Civil Environm & Mech Engn, Trento, Italy
5.Zhejiang Univ, Soft Matter Res Ctr, Dept Engn Mech, Hangzhou 310027, Peoples R China
6.Qihang Union & Innovat Ctr, Huanjiang Lab, Zhuji 311800, Peoples R China
7.Ctr Soft Machines & Smart Devices, Huanjiang Lab, Zhuji 311800, Peoples R China
8.Harbin Inst Technol, Ctr Composite Mat & Struct, Harbin 150001, Peoples R China

Wang, Yafei,Li, Zhanfeng,Chen, Xingmei,et al. Electroactive differential growth and delayed instability in accelerated healing tissues[J]. JOURNAL OF THE MECHANICS AND PHYSICS OF SOLIDS,2024,193.

Wang, Yafei.,Li, Zhanfeng.,Chen, Xingmei.,Tan, Yun.,Wang, Fucheng.,...&Liu, Ji.(2024).Electroactive differential growth and delayed instability in accelerated healing tissues.JOURNAL OF THE MECHANICS AND PHYSICS OF SOLIDS,193.

Wang, Yafei,et al."Electroactive differential growth and delayed instability in accelerated healing tissues".JOURNAL OF THE MECHANICS AND PHYSICS OF SOLIDS 193(2024).