南方科技大学知识苑(SUSTech KC): The Preventive and Therapeutic Effects of Acute and Severe Inflammatory Disorders with Heparin and Heparinoid

题名	The Preventive and Therapeutic Effects of Acute and Severe Inflammatory Disorders with Heparin and Heparinoid
作者	Song, Ying 1; Wu, Yuxiang 1; Ding, Fangfang 1; Li, Shuo2 ; Shen, Yaojia 1; Yang, Bingyan 1; Tang, Xinran 1; Ren, Lige 3; Deng, Lirong 3; Jin, Xuewen 3; Yan, Yishu 1
通讯作者	Yan, Yishu
发表日期	2024-09-01
DOI	10.3390/biom14091078
发表期刊	BIOMOLECULES 影响因子和分区
EISSN	2218-273X
卷号	14 期号:9
摘要	Systematic inflammatory response syndrome (SIRS) and the accompanying sepsis pose a huge threat to human health worldwide. Heparin is a part of the standard supportive care for the disease. However, the molecular mechanism is not fully understood yet, and the potential signaling pathways that play key roles have not yet been elucidated. In this paper, the main findings regarding the molecular mechanisms associated with the beneficial effects of heparin, including inhibiting HMGB-1-driven inflammation reactions, histone-induced toxicity, thrombo-inflammatory response control and the new emerging mechanisms are concluded. To set up the link between the preclinical research and the clinical effects, the outcomes of the clinical trials are summarized. Then, the structure and function relationship of heparin is discussed. By providing an updated analysis of the above results, the paper highlights the feasibility of heparin as a possible alternative for sepsis prophylaxis and therapy.
关键词	sepsis heparin COVID-19 anti-inflammation structure and function relationship
相关链接	[来源记录]
收录类别	SCI
语种	英语
学校署名	其他
资助项目	Shenzhen Science and Technology Program[KJZD20230923114706013] ; Postgraduate Research and Practice Innovation Program of Jiangsu Province[KYCX23_2576]
WOS研究方向	Biochemistry & Molecular Biology
WOS类目	Biochemistry & Molecular Biology
WOS记录号	WOS:001323686900001
出版者	MDPI
来源库	Web of Science
引用统计
成果类型	期刊论文
条目标识符	http://sustech.caswiz.com/handle/2SGJ60CL/835350
专题	南方科技大学
作者单位	1.Jiangnan Univ, Sch Life Sci & Hlth Engn, Wuxi 214122, Peoples R China 2.Southern Univ Sci & Technol, Medi X Pingshan, Shenzhen 518118, Peoples R China 3.Shenzhen Hepalink Pharmaceut Grp Co Ltd, Shenzhen 518057, Peoples R China
推荐引用方式 GB/T 7714	Song, Ying,Wu, Yuxiang,Ding, Fangfang,et al. The Preventive and Therapeutic Effects of Acute and Severe Inflammatory Disorders with Heparin and Heparinoid[J]. BIOMOLECULES,2024,14(9).
APA	Song, Ying.,Wu, Yuxiang.,Ding, Fangfang.,Li, Shuo.,Shen, Yaojia.,...&Yan, Yishu.(2024).The Preventive and Therapeutic Effects of Acute and Severe Inflammatory Disorders with Heparin and Heparinoid.BIOMOLECULES,14(9).
MLA	Song, Ying,et al."The Preventive and Therapeutic Effects of Acute and Severe Inflammatory Disorders with Heparin and Heparinoid".BIOMOLECULES 14.9(2024).