Mechanism of Self-Assembled Celastrol-Erianin Nanomedicine for treatment of breast cancer

Tian, Jiahang1,2,3,4,7,8; Chen, Kun1,2,3,4; Zhang, Qian1,2,3,4,7,8; Qiu, Chong1,2,5,6; Tong, Haibo1,2; Huang, Jingnan1,2; Hao, Mingjing1,2,7,8; Chen, Junhui1,2; Zhao, Wentong1,2; Wong, Yin-Kwan1,2,9; Gao, Lei1,2,3,4,7,8; Luo, Piao1,2,3,4,7,8; Wang, Jigang1,2,3,4,5,6,8; Du, Qingfeng1,2,3,4,7,8

2024-11-01

10.1016/j.cej.2024.155709

CHEMICAL ENGINEERING JOURNAL   影响因子和分区

1385-8947

1873-3212

Apoptosis as a common form of programmed cell death, plays a crucial role in tumor therapy. Celastrol and erianin are natural compounds extracted from plants. Celastrol exhibits cytotoxic effects on various tumor cells through mechanisms such as ferroptosis and apoptosis, while erianin significantly inhibits the growth and metastasis of cancer cells. However, the high toxicity of celastrol and the low water solubility of both compounds hinder their clinical applications. In this study, nanoparticles (CEN) self-assembled from celastrol and erianin were designed to enhance drug solubility and tumor-targeting capability. These nanoparticles significantly inhibited the proliferation of tumor cells while effectively killing the entire tumor cell population. Additionally, using activity-based protein profiling (ABPP) and a celastrol-probe (cel-p), Annexin A2 was identified as the target of celastrol in 4 T1 cells. Proteomics was subsequently used to evaluate the changes in protein expression induced by CEN. In a mouse model of breast cancer, CEN demonstrated superior tumor-targeting ability and prolonged action due to the enhanced permeability and retention (EPR) effect, resulting in better therapeutic efficacy with lower systemic toxicity. In conclusion, this study provides a novel reference for the treatment of breast cancer.

Self-assembling Celastrol Erianin ABPP Annexin A2 Target

SCI

英语

第一 ; 通讯

Project of Guangzhou City["2024A04J4155","2024A04J4573"] ; Guangdong Provincial Bureau of Traditional Chinese Medicine research project["20241202","20241205"] ; Shenzhen Governmental Sustainable Development Fund[KCXFZ20201221173612034] ; Shenzhen key Labo-ratory of Kidney Diseases[ZDSYS201504301616234] ; Shenzhen Fund for Guangdong Provincial High-level Clinical Key Specialties[SZGSP001]

Engineering

Engineering, Environmental ; Engineering, Chemical

WOS:001322753500001

ELSEVIER SCIENCE SA

Web of Science

1.Southern Univ Sci & Technol, Jinan Univ 2, Shenzhen Peoples Hosp, Guangdong Prov Clin Res Ctr Geriatr,Shenzhen Inst, Shenzhen 518020, Guangdong, Peoples R China
2.Southern Univ Sci & Technol, Jinan Univ 2, Shenzhen Peoples Hosp, Shenzhen Clin Res Ctr Geriatr,Affiliated Hosp 1,Cl, Shenzhen 518020, Guangdong, Peoples R China
3.Southern Med Univ, Sch Tradit Chinese Med, Guangzhou 510515, Guangdong, Peoples R China
4.Southern Med Univ, Sch Pharmaceut Sci, Guangzhou 510515, Guangdong, Peoples R China
5.China Acad Chinese Med Sci, Artemisinin Res Ctr, State Key Lab Qual Ensurance & Sustainable Use Dao, Beijing 100700, Peoples R China
6.China Acad Chinese Med Sci, Inst Chinese Mat Med, Beijing 100700, Peoples R China
7.Southern Med Univ, Guangdong Prov Key Lab Chinese Med Pharmaceut, Guangzhou 510515, Peoples R China
8.Guangdong Basic Res Ctr Excellence Integrated Trad, Guangzhou 510515, Peoples R China
9.Natl Univ Singapore, Dept Biol Sci, Singapore 117543, Singapore

Tian, Jiahang,Chen, Kun,Zhang, Qian,et al. Mechanism of Self-Assembled Celastrol-Erianin Nanomedicine for treatment of breast cancer[J]. CHEMICAL ENGINEERING JOURNAL,2024,499.

Tian, Jiahang.,Chen, Kun.,Zhang, Qian.,Qiu, Chong.,Tong, Haibo.,...&Du, Qingfeng.(2024).Mechanism of Self-Assembled Celastrol-Erianin Nanomedicine for treatment of breast cancer.CHEMICAL ENGINEERING JOURNAL,499.

Tian, Jiahang,et al."Mechanism of Self-Assembled Celastrol-Erianin Nanomedicine for treatment of breast cancer".CHEMICAL ENGINEERING JOURNAL 499(2024).