Association of CYP7B1 expression with the prognosis of endometrial cancer: a retrospective study

Lu，Xiao Fang1; Huang，Tao2; Chen，Chang3; Zhang，Jing1; Fu，Xu Yong1; Cheng，Bo4; Zhou，Ya Yan5; Lei，Jia2; Lu，Da Lin1

2024-12-01

10.1186/s12957-024-03504-4

World Journal of Surgical Oncology   影响因子和分区

1477-7819

Background: Endometrial cancer (EC) tissues express CYP7B1, but its association with prognosis needs to be investigated. Methods: Immunohistochemistry and image analysis software were used to assess CYP7B1 protein expression in paraffin-embedded endometrial tumor sections. Associations between CYP7B1 and clinical factors were tested with the Wilcoxon rank-sum test. Kaplan-Meier curves were employed to describe survival, and differences were assessed using the log-rank test. Cox regression analysis was used to assess the association between CYP7B1 expression and the prognosis of patients with EC. Results: A total of 307 patients were enrolled with an average age of 52.6 ± 8.0 years at diagnosis. During the period of follow-up, 46 patients (15.0%) died, and 29 (9.4%) suffered recurrence. The expression of CYP7B1 protein is significantly higher in the cytoplasm than in the nucleus (P < 0.001). Patients aged < 55 years (P = 0.040), ER-positive patients (P = 0.028) and PR-positive patients (P < 0.001) report higher levels of CYP7B1 protein. Both univariate (HR = 0.41, 95% CI: 0.18–0.90, P = 0.025) and multivariate (HR = 0.35, 95%CI:0.16–0.79, P = 0.011) Cox regression analyses demonstrate that high CYP7B1 protein expression predicts longer overall survival (OS). When considering only ER-positive patients (n = 265), CYP7B1 protein expression is more strongly associated with OS (HR = 0.20,95%CI:0.08–0.52, P = 0.001). The 3-year OS and 5-year OS in the low-CYP7B1 subgroup are 81.6% and 76.8%, respectively; while in the high-CYP7B1 subgroup are 93.0% and 92.0%, respectively (P = 0.021). Conclusions: High CYP7B1 protein expression predicted longer OS, suggesting that it may serve as an important molecular marker for EC prognosis.

CYP7B1 Endometrial cancer Estrogen receptor Overall survival

英语

其他

2-s2.0-85204282024

Scopus

1.Department of Epidemiology,School of Medicine,Jinan University,Guangzhou,No. 601, Huangpu Avenue West, Tianhe District,510632,China
2.Department of Gynecology,Wuzhou Red Cross Hospital,Wuzhou,No. 3-1, Xinxing 1st Road, Wanxiu District,543002,China
3.Department of Pathology,Wuzhou Red Cross Hospital,Wuzhou,China
4.Department of Pathology,Chinese People’s Liberation Army Rocket Force Characteristic Medical Center,Beijing,China
5.Department of Radiation Oncology,Shenzhen People’s Hospital (The Second Clinical Medical College,Jinan University; The First Affiliated Hospital,Southern University of Science and Technology),Shenzhen,China

Lu，Xiao Fang,Huang，Tao,Chen，Chang,et al. Association of CYP7B1 expression with the prognosis of endometrial cancer: a retrospective study[J]. World Journal of Surgical Oncology,2024,22(1).

Lu，Xiao Fang.,Huang，Tao.,Chen，Chang.,Zhang，Jing.,Fu，Xu Yong.,...&Lu，Da Lin.(2024).Association of CYP7B1 expression with the prognosis of endometrial cancer: a retrospective study.World Journal of Surgical Oncology,22(1).

Lu，Xiao Fang,et al."Association of CYP7B1 expression with the prognosis of endometrial cancer: a retrospective study".World Journal of Surgical Oncology 22.1(2024).