南方科技大学知识苑(SUSTech KC): Abnormal Cellular Populations Shape Thymic Epithelial Tumor Heterogeneity and Anti-Tumor by Blocking Metabolic Interactions in Organoids

题名	Abnormal Cellular Populations Shape Thymic Epithelial Tumor Heterogeneity and Anti-Tumor by Blocking Metabolic Interactions in Organoids
作者	Liu, Xuefei1,2,3 ; Wang, Changchun 4; Huang, Yueyu 1; Lv, Qiaoli 5; Yu, Chang 6; Ying, Jianghua 7; Duan, Lianhui2 ; Guo, Yangzhong 5; Huang, Guanyin2 ; Shen, Wenhui 1; Jiang, Ming 8,9; Mao, Weimin 5,10; Zuo, Zhixiang 11; Zhao, An 1,5
通讯作者	Mao, Weimin; Zuo, Zhixiang; Zhao, An
发表日期	2024
DOI	10.1002/advs.202406653
发表期刊	Advanced Science 影响因子和分区
EISSN	2198-3844
摘要	A variety of abnormal epithelial cells and immature and mature immune cells in thymic epithelial tumors (TETs) affect histopathological features, the degree of malignancy, and the response to treatment. Here, gene expression, trajectory inference, and T cell antigen receptor (TCR)-based lineage tracking are profiled in TETs at single-cell resolution. An original subpopulation of KRT14⁺ progenitor cells with a spindle cell phenotype is shown. An abnormal infiltration of immature T cells with a TCR hyper-rearrangement state is revealed, due to the lack of CCL21⁺ medullary epithelial cells. For thymic carcinoma, the novel biomarkers of MSLN, CCL20, and SLC1A5 are identified and observed an elevated expression of LAG3 and HAVCR2 in malignant tumorn-infiltrating mature T cells. These common features based on the single-cell populations may inform pathological reclassification of TETs. Meanwhile, it is found that macrophages (MACs) attract thymic tumor cells through the LGALS9-SLC1A5 axis, providing them with glutamine to elicit metabolic reprogramming. This MAC-based metabolic pattern can promote malignancy progression. Additionally, an interactive immune environment in TETs is identified that correlates with the infiltration of abnormal FOXI1⁺ CFTR⁻ ionocytes. Collectively, the data broaden the knowledge of TET cellular ecosystems, providing a basis for tackling histopathological diagnosis and related treatment. © 2024 The Author(s). Advanced Science published by Wiley-VCH GmbH.
收录类别	EI
语种	英语
学校署名	其他
资助项目	This work was supported by the National Natural Science Foundation of China (82172567) and the Key R&D plan of Jiangxi Province (2021BBG71006).
出版者	John Wiley and Sons Inc
EI入藏号	20243717030962
EI主题词	Antigens ; Cell culture ; T-cells
EI分类号	:101.3 ; :101.7 ; :102.2.1 ; :103 ; :103.2
来源库	EV Compendex
引用统计
成果类型	期刊论文
条目标识符	http://sustech.caswiz.com/handle/2SGJ60CL/841001
专题	南方科技大学医学院_生物化学系南方科技大学南方科技大学医学院
作者单位	1.Zhejiang Cancer Institute, Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Zhejiang, Hangzhou; 310022, China 2.Department of Biochemistry, School of Medicine, Southern University of Science and Technology, Shenzhen; 518055, China 3.Shenzhen Institute of Pediatrics, Shenzhen Children's Hospital, Shenzhen; 518026, China 4.Department of Thoracic Oncology, Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Zhejiang, Hangzhou; 310022, China 5.Thoracic Oncology Laboratory, Jiangxi Cancer Hospital, Nanchang Medical College, Jiangxi, Nanchang; 330029, China 6.Department of Pathology, Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Zhejiang, Hangzhou; 310022, China 7.Department of Ultrasound, Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Zhejiang, Hangzhou; 310022, China 8.Center for Genetic Medicine, The Fourth Affiliated Hospital, Zhejiang University School of Medicine, Zhejiang, Hangzhou; 310011, China 9.Zhejiang Provincial Key Laboratory of Genetic & Developmental Disorders, Zhejiang, Hangzhou; 310011, China 10.Zhejiang Provincial Key Laboratory of Diagnosis and Treatment of Thoracic Cancer, Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Zhejiang, Hangzhou; 310022, China 11.State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou; 510308, China
第一作者单位	生物化学系; 南方科技大学医学院
推荐引用方式 GB/T 7714	Liu, Xuefei,Wang, Changchun,Huang, Yueyu,et al. Abnormal Cellular Populations Shape Thymic Epithelial Tumor Heterogeneity and Anti-Tumor by Blocking Metabolic Interactions in Organoids[J]. Advanced Science,2024.
APA	Liu, Xuefei.,Wang, Changchun.,Huang, Yueyu.,Lv, Qiaoli.,Yu, Chang.,...&Zhao, An.(2024).Abnormal Cellular Populations Shape Thymic Epithelial Tumor Heterogeneity and Anti-Tumor by Blocking Metabolic Interactions in Organoids.Advanced Science.
MLA	Liu, Xuefei,et al."Abnormal Cellular Populations Shape Thymic Epithelial Tumor Heterogeneity and Anti-Tumor by Blocking Metabolic Interactions in Organoids".Advanced Science (2024).