南方科技大学知识苑(SUSTech KC): Ir-catalyzed chemo- and enantioselective hydrogenation of enyne-conjugated ketones

题名	Ir-catalyzed chemo- and enantioselective hydrogenation of enyne-conjugated ketones
作者	Zheng, Xuejuan 1,2; Huang, Fanping1 ; Yu, Jianfei1 ; Lang, Qiwei 1; Duan, Ya-Nan 4; Chen, Gen-Qiang3 ; Zhang, Xumu1,4
通讯作者	Chen, Gen-Qiang; Zhang, Xumu
发表日期	2024
DOI	10.1039/d4qo01362j
发表期刊	Organic Chemistry Frontiers 影响因子和分区
ISSN	2052-4110
EISSN	2052-4129
摘要	The asymmetric hydrogenation of β-alkynyl α,β-unsaturated ketones has been achieved by using Ir/f-phamidol as a catalyst under mild conditions, providing the corresponding chiral alcohols in high yields (up to 99% yield) and with excellent enantioselectivities (up to 99% ee). Moreover, the reaction performed well on a gram scale with 0.1 mol% catalytic loading, indicating the potential use of this protocol in the synthesis of chiral alkyl alcohols, drugs and natural products. © 2024 The Royal Society of Chemistry.
收录类别	EI
语种	英语
学校署名	第一 ; 通讯
资助项目	G.-Q. Chen gratefully acknowledges financial support from the National Key R&D Program of China (2021YFF0701604), the National Natural Science Foundation of China (No. 22171129), the Shenzhen Science and Technology Innovation Committee (JCYJ20210324104202007) and the Guangdong Basic and Applied Basic Research Foundation (2022B1515020055). X. Zhang is indebted to the Chemistry and Chemical Engineering Guangdong Laboratory (Grant no. 2011006 and 2132013), the Stable Support Plan Program of Shenzhen Natural Science Fund (Program Contract No. 20200925161222002), the Key-Area Research and Development Program of Guangdong Province (No. 2020B010188001), the Innovative Team of Universities in Guangdong Province (No. 2020KCXTD016) and the National Natural Science Foundation of China (No. 21991113) for providing financial support. The authors acknowledge the assistance of SUSTech Core Research Facilities.
出版者	Royal Society of Chemistry
EI入藏号	20243817077605
EI主题词	Catalysis ; Hydrogenation
EI分类号	Chemistry, General:801.1 ; Chemical Reactions:802.2
来源库	EV Compendex
引用统计
成果类型	期刊论文
条目标识符	http://sustech.caswiz.com/handle/2SGJ60CL/841081
专题	理学院_化学系南方科技大学前沿与交叉科学研究院深圳格拉布斯研究院
作者单位	1.Medi-X Pingshan, Guangdong Provincial Key Laboratory of Catalysis, and Department of Chemistry, Southern University of Science and Technology, Shenzhen; 518000, China 2.Shenzhen Grubbs Institute, Department of Chemistry, Southern University of Science and Technology, Shenzhen; 518000, China 3.Academy for Advanced Interdisciplinary Studies, Shenzhen Grubbs Institute, Southern University of Science and Technology, Shenzhen; 518000, China 4.Chemistry and Chemical Engineering Guangdong Laboratory, Shantou; 515031, China
第一作者单位	化学系; 深圳格拉布斯研究院
通讯作者单位	深圳格拉布斯研究院; 前沿与交叉科学研究院; 化学系
第一作者的第一单位	化学系
推荐引用方式 GB/T 7714	Zheng, Xuejuan,Huang, Fanping,Yu, Jianfei,et al. Ir-catalyzed chemo- and enantioselective hydrogenation of enyne-conjugated ketones[J]. Organic Chemistry Frontiers,2024.
APA	Zheng, Xuejuan.,Huang, Fanping.,Yu, Jianfei.,Lang, Qiwei.,Duan, Ya-Nan.,...&Zhang, Xumu.(2024).Ir-catalyzed chemo- and enantioselective hydrogenation of enyne-conjugated ketones.Organic Chemistry Frontiers.
MLA	Zheng, Xuejuan,et al."Ir-catalyzed chemo- and enantioselective hydrogenation of enyne-conjugated ketones".Organic Chemistry Frontiers (2024).