Differential effects of lifetime stressors on major depressive disorder severity: a longitudinal community-based cohort study

Su, Yingying1,2,3; Li, Muzi2,3; Caron, Jean2,3; Li, Daqi5; Meng, Xiangfei2,3,4

2024-10-04

10.1192/j.eurpsy.2024.1783

EUROPEAN PSYCHIATRY   影响因子和分区

0924-9338

1778-3585

Background Stressors across the lifespan are associated with the onset of major depressive disorder (MDD) and increased severity of depressive symptoms. However, it is unclear how lifetime stressors are related to specific MDD subtypes. The present study aims to examine the relationships between MDD subtypes and stressors experienced across the lifespan while considering potential confounders.Methods Data analyzed were from the Zone d'& Eacute;pid & eacute;miologie Psychiatrique du Sud-Ouest de Montr & eacute;al (N = 1351). Lifetime stressors included childhood maltreatment, child-parent bonding, and stressful life events. Person-centered analyses were used to identify the clusters/profiles of the studied variables and multinomial logistic regression analyses were performed to examine the relationships between stressors and identified MDD subtypes. Intersectional analysis was applied to further examine how distal stressors interact with proximal stressors to impact the development of MDD subtypes.Results There was a significant association between proximal stressors and melancholic depression, whereas severe atypical depression and moderate depression were only associated with some domains of stressful life events. Additionally, those with severe atypical depression and melancholic depression were more likely to be exposed to distal stressors such as childhood maltreatment. The combinations of distal and proximal stressors predicted a greater risk of all MDD subtypes except for moderate atypical depression.Conclusions MDD was characterized into four subtypes based on depressive symptoms and severity. Different stressor profiles were linked with various MDD subtypes. More specific interventions and clinical management are called to provide precision treatment for MDD patients with unique stressor profiles and MDD subtypes.

general psychopathology lifetime stressors longitudinal data major depressive disorder subtypes

SCI ; SSCI

英语

第一

Canadian Institute of Health Research["CTP-79839","PJT-148845"]

Psychiatry

Psychiatry

WOS:001325852600001

CAMBRIDGE UNIV PRESS

Web of Science

1.Southern Univ Sci & Technol, Sch Publ Hlth & Emergency Management, Shenzhen, Peoples R China
2.McGill Univ, Fac Med & Hlth Sci, Dept Psychiat, Montreal, PQ, Canada
3.Douglas Res Ctr, Div Mental Hlth & Soc, Montreal, PQ, Canada
4.Univ Ottawa, Fac Hlth Sci, Interdisciplinary Sch Hlth Sci, Ottawa, ON, Canada
5.Chongqing Med Univ, Univ Town Hosp, Mental Hlth Ctr, Chongqing, Peoples R China

Su, Yingying,Li, Muzi,Caron, Jean,et al. Differential effects of lifetime stressors on major depressive disorder severity: a longitudinal community-based cohort study[J]. EUROPEAN PSYCHIATRY,2024,67(1).

Su, Yingying,Li, Muzi,Caron, Jean,Li, Daqi,&Meng, Xiangfei.(2024).Differential effects of lifetime stressors on major depressive disorder severity: a longitudinal community-based cohort study.EUROPEAN PSYCHIATRY,67(1).

Su, Yingying,et al."Differential effects of lifetime stressors on major depressive disorder severity: a longitudinal community-based cohort study".EUROPEAN PSYCHIATRY 67.1(2024).